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 | Blogs > Kav1ta > Live and Let Live > Something Different .... only for openminded minds |
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Kav1ta
10/1/2008 9:15 pmLast Read: |
The length of this post is intentionally long so that only those who are seriously interested in the subject may read it. LONDON (Reuters) - A Chinese herbal remedy called horny goat weed is a promising alternative to Viagra for impotent men, Italian researchers said on Monday.  The herb has long held a reputation as a natural aphrodisiac. The lab experiments, which did not look at whether the plant actually increases desire, could lead to new drugs to help men get erections, said Mario Dell'Agli, a researcher at the University of Milan, who led the study. "This could be the natural Viagra," he said in a telephone interview. "The novelty is that we have synthesized a new molecule that one day may be able to replace Viagra." Erectile dysfunction is a common condition worldwide, and drugs like Pfizer Inc's Viagra, Eli Lilly and Co's Cialis or tadalafil, and Bayer AG's Levitra or vardenafil, work by increasing blood flow to the genitals. But the medicines, which inhibit an enzyme called phosphodiesterase type 5 that restricts blood flow around the body, including to the penis, can have side effects ranging from headaches, upset stomach and visual problems including blindness. The Italian team looked for alternatives by studying a number of plants reputed to boost sexual performance. After homing in on horny goat weed, the researchers modified a compound in the plant called icariin and found it blocked the erection-inhibiting enzyme as well as Viagra did. Because the compound targets the enzyme more precisely, it may have fewer side effects than Viagra, known generically as sildenafil, Dell'Agli said. Further tests in animals and humans are needed but the extract from the herb represents a potential new erectile dysfunction treatment with fewer side effects, Dell'Agli said. "The compound icariin is present in the horny goat weed in large amounts and its activity against (the enzyme) is lower compared to Viagra," he said. "But the new molecule we synthesized from icariin is as good as Viagra against (the enzyme)." (Reporting by Michael Kahn; Editing by Maggie Fox and Elizabeth Piper) Sharon Kirkey, Canwest News Service Published: Monday, September 29, 2008Italian researchers are testing a promising alternative to Viagra that they're calling 3,7-bis-(2-hydroxyethyl)-icaritin -- or more simply put, "horny goat weed." In lab experiments, a semi-synthetic derivative of the active compound in Epimedium brevicornum, an ancient Chinese herbal remedy for impotence, performed as well as Viagra but with the potential for fewer side effects, the researchers say. It's an ironic finding: Health Canada has issued a string of warnings on Chinese herbal products for erectile dysfunction because they contain undeclared sildenafil -- the active ingredient in Viagra. Now, a Chinese aphrodisiac may outperform the blockbuster drug. The study is scheduled for the Oct. 24 issue of the American Chemical Society's Journal of Natural Products. "The inability to achieve or maintain an erection sufficient for satisfactory sexual function is an increasing problem with a considerable impact on interpersonal relationships and quality of life for men," the researchers write. During sexual arousal, a chemical called cyclic GMP causes smooth muscle to relax, increasing blood flow to the penis. Viagra works by blocking an enzyme that normally breaks down this chemical. This allows more blood to flow to and be trapped in the penis, resulting in an erection. But, "sildenafil (Viagra) shows a lot of side effects including headache, facial flushing and visual disturbances," says lead author Mario Dell-Agli, from the department of pharmacological sciences at Milan University. "So it is important to search for new alternatives to Viagra." His group studied medicinal plants that had a reputation in the literature for their aphrodisiac effects. They tested four. Only one, "horny goat weed," was strongly active against the enzyme that inhibits blood flow to the penis. But it needed improvement to match Viagra's potency. When the researchers chemically modified the active compound, they came up with something "as potent as sildenafil on the enzyme," Dell-Agli says. And because it targeted the enzyme more precisely, it could have fewer side effects, he says. It hasn't been tested in humans. But, "this molecule, in my opinion, can be considered a candidate worthy of further studies," Dell-Agli says. The study is scheduled for the Oct. 24 issue of the American Chemical Society's Journal of Natural Products. "The inability to achieve or maintain an erection sufficient for satisfactory sexual function is an increasing problem with a considerable impact on interpersonal relationships and quality of life for men," the researchers write. During sexual arousal, a chemical called cyclic GMP causes smooth muscle to relax, increasing blood flow to the penis. Viagra works by blocking an enzyme that normally breaks down this chemical. This allows more blood to flow to and be trapped in the penis, resulting in an erection. But, "sildenafil (Viagra) shows a lot of side effects including headache, facial flushing and visual disturbances," says lead author Mario Dell-Agli, from the department of pharmacological sciences at Milan University. "So it is important to search for new alternatives to Viagra." His group studied medicinal plants that had a reputation in the literature for their aphrodisiac effects. They tested four. Only one, "horny goat weed," was strongly active against the enzyme that inhibits blood flow to the penis. Why worry and have wrinkles ... When you can smile and have dimples 
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 10/1/2008 10:25 pm |
Oct. 24  Date younger men! 
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10/2/2008 4:11 am |
horny goat weed........ =Viagra......... October 24.......  
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10/3/2008 3:53 am |
Kind Awesome Very Intelligent True Angel... Sweet KAVITA... HMMMMMMMMMMMMMMM................... BEAUITFUL AND KNOWLDGEABLE POST BABE WITH LOVE ------------- LOVE U HUNGRY 
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10/3/2008 11:47 pm |
This could come useful especially for older guys who can afford the company of classy younger escorts. VASHALAN
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10/11/2008 8:05 am |
lolzzz Love doesnt need all this but lust does. Lust = Viagara; love = unquestioning loyalty and never having to say you are sorry. So if the tool doesnt work, maybe thats yr lot in life. But am sure many will disagree with me....chk the other blogs fr my new addy Take care and hope to hear from you soon.I been away on hols so thts y u didnt hear from me earlier chidoo
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10/12/2008 7:18 am |
Oct. 24 Date younger men!  That goes without saying  Why worry and have wrinkles ... When you can smile and have dimples
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10/12/2008 7:20 am |
horny goat weed........ =Viagra......... October 24.......You seem a trifle confused here  Why worry and have wrinkles ... When you can smile and have dimples
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10/12/2008 7:21 am |
Kind Awesome Very Intelligent True Angel... Sweet KAVITA... HMMMMMMMMMMMMMMM................... BEAUITFUL AND KNOWLDGEABLE POST BABE WITH LOVE ------------- LOVE U HUNGRY Nice to see you again  Why worry and have wrinkles ... When you can smile and have dimples
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10/12/2008 7:24 am |
This could come useful especially for older guys who can afford the company of classy younger escorts. Maybe that is why I never go out with those who need either Thanks for stopping by. Why worry and have wrinkles ... When you can smile and have dimples
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10/12/2008 7:28 am |
lolzzz Love doesnt need all this but lust does. Lust = Viagara; love = unquestioning loyalty and never having to say you are sorry. So if the tool doesnt work, maybe thats yr lot in life. But am sure many will disagree with me....chk the other blogs fr my new addy Take care and hope to hear from you soon.I been away on hols so thts y u didnt hear from me earlier chidoo Agree with you that the best is still 'au naturale'. It's the seniors who will benefit from this Thanks for stopping by. Why worry and have wrinkles ... When you can smile and have dimples
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10/12/2008 7:57 am |
Hi, Kaviths, You are doing immence service to the men who are impotent. Some men suffer from andropause, some from depression and others from lack of love. Any way if that medicine works it will create lot of demand for women. In my cae, however, a sexy and beautiful woman would work like viagra!
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11/1/2008 9:03 pm |
Hi Arudra Welcome to my space You are correct with your statements that there can be many causes for 'inefficiency'. And as you correctly indicated, lack of love can be a major factor  Thank you for your contribution  Why worry and have wrinkles ... When you can smile and have dimples
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 11/4/2008 10:08 am |
as i presently do not have the problem i cant comment on this ...but there are a large number of other grugs and capsules in indian market...only one who has tested can cofidently reply.... With Love......always AND in all ways!!!!!!
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